Author

S. M. Haslam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Dell· 4 shared A. Antonopoulos· 2 shared L. Bouche· 2 shared S. Neelamegham· 2 shared A. Addhya· 1 shared A. Chernykh· 1 shared A. E. Friedman· 1 shared A. Filer· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersImmunology

A. Dell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Decreased fucosylation impacts epithelial integrity and increases risk for COPD.

C. Swaby, B. Yeung-Luk, S. Thapa, K. Nishida, A. Wally, B. Ghosh, A. Niederkofler, S. Luk, M. Girgis, A. Keller, C. Cortez, S. Ramaswamy, K. Wilmsen, L. Bouche, A. Dell, , V. K. Sidhaye

This study shows decreased fucosylation impairs epithelial integrity and increases COPD risk by affecting E-cadherin function and cell differentiation.

bioRxiv · Oct 31, 2023 · PreprintCell Biology

Immobilised enzyme cascade for targeted glycosylation

E. Makrydaki, R. Donini, A. Krueger, K. E. Royle, I. Moya Ramirez, D. A. Kuntz, D. R. Rose, S. M. Haslam, K. M. Polizzi, C. Kontoravdi

The paper introduces a platform for controlled N-linked glycosylation using immobilized enzymes, achieving high conversion and reusability for industrial applications.

bioRxiv · Apr 8, 2022 · PreprintBioengineering

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

R. Kawahara, A. Chernykh, K. Alagesan, M. Bern, W. Cao, R. J. Chalkley, K. Cheng, M. S. Choo, N. Edwards, R. Goldman, M. Hoffmann, Y. Hu, Y. Huang, J. Y. Kim, D. Kletter, , Palmisano

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

Efficient Inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc

S.-S. Wang, V. del Solar, X. Yu, A. Antonopoulos, A. E. Friedman, K. Agarwal, M. Garg, S. M. Ahmed, A. Addhya, M. Nasirikenari, J. T. Lau, A. Dell, S. M. Haslam, S.-G. Sampathkumar, S. Neelamegham

This paper demonstrates that Ac5GalNTGc is a potent inhibitor of O-glycan biosynthesis, effectively reducing O-glycan elongation and modulating leukocyte functions.

bioRxiv · Dec 13, 2020Biochemistry

Regulatory T cell activation triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses

G. Wu, G. Murugesan, M. Nagala, A. McCraw, S. M. Haslam, A. Dell, P. R. Crocker

The paper investigates how Siglec-1 binding to activated regulatory T cells changes with glycosylation and identifies potential Siglec-1 counter-receptors.

bioRxiv · Jul 29, 2020 · PreprintImmunology

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in Rheumatoid Arthritis.

Y. Wang, A. Khan, A. Antonopoulos, L. Bouche, C. D. Buckley, A. Filer, K. Raza, K. Ping-Li, B. Tolusso, E. Gremese, M. Kurowska-Stolarska, S. Alivernini, A. Dell, S. M. Haslam, M. A. Pineda

This study shows that reduced α2-6 sialylation in synovial fibroblasts contributes to a pro-inflammatory phenotype in RA by altering glycosylation pathways.

bioRxiv · Mar 8, 2020Immunology