R. Kawahara

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

Structural basis for lysophosphatidylserine recognition by GPR34

This study presents cryo-EM structures of GPR34-Gi complex bound with LysoPS analogs, revealing ligand recognition mechanisms and identifying 2-acyl LysoPS as the physiological ligand.

Comprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival

The paper analyzes N-glycosylation patterns in oral tumours to identify glyco-markers linked to lymph node metastasis and patient survival.

Oligomannosylation and MAN1A1 expression associate strongly with a subset of human cancer types

The paper identifies oligomannosylation and MAN1A1 expression as strongly associated with specific human cancers through glycomics analysis and MALDI-MS imaging.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Hyper-Truncated Glycans Augment the Activity of Neutrophil Granule Myeloperoxidase

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.