R. L. Belote

Human melanocyte development and melanoma dedifferentiation at single cell resolution

This study characterizes human melanocyte development and dedifferentiation using single-cell RNA-sequencing, identifying site-specific subpopulations and transcriptional programs distinct from model systems.

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.

BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB.

This study identifies microRNA-mediated suppression of AURKB as a mechanism by which BRAFV600E induces reversible mitotic arrest in human melanocytes, contributing to nevus formation.

Cell-cell signaling elicits local Ca2+ transients in melanocyte dendrites and dendritic spine-like structures

The paper shows that human melanocytes exhibit local Ca2+ transients in dendrites and spines when co-cultured with keratinocytes, driven by secreted factors.