Author

S. M. Stagg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 5 Research Focus:protein folding & dynamics· 4 Assay:structural biology· 3 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

P. S. Randolph· 4 shared A. Mehrani· 3 shared J. H. Mendez· 3 shared C. M. Dunham· 2 shared E. D. Hoffer· 2 shared A. E. Jerse· 1 shared A. K. Paravastu· 1 shared A. S. Roband· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

P. S. Randolph

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer's Amyloid-β Oligomer

Y. Gao, R. Prasad, P. S. Randolph, J. O. Watzlawik, A. S. Roband, C. Guo, S. M. Stagg, H.-X. Zhou, T. L. Rosenberry, A. K. Paravastu

The paper presents a structural model of an Alzheimer's Aβ42 oligomer based on solid-state NMR and cryo-EM data, explaining its stability and ion permeability.

bioRxiv · Dec 6, 2022 · PreprintBiochemistry

Characterizing the Resolution and Throughput of the Apollo Direct Electron Detector

R. Peng, X. Fu, J. H. Mendez, P. S. Randolph, B. E. Bammes, S. M. Stagg

The paper evaluates the Apollo direct electron detector's performance in cryo-EM, showing high-resolution reconstructions across different dose rates and sample sizes.

bioRxiv · Sep 16, 2022Biochemistry

Adeno-associated Virus Receptor-binding: Flexible Domains and Alternative Conformations through cryo-Electron Tomography of AAV2 and AAV5 complexes

G. Hu, M. A. Silveria, M. S. Chapman, S. M. Stagg

This paper uses cryo-ET to reveal flexible domains and alternative conformations of AAV2 and AAV5 receptor complexes, showing structural complexity relevant to viral entry and gene therapy.

bioRxiv · Jan 10, 2022 · PreprintMicrobiology

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Z. D. Aron, A. Mehrani, E. D. Hoffer, K. L. Connolly, M. C. Torhan, J. N. Alumasa, P. Srinivas, M. Cabrera, D. Hosangadi, J. S. Barbor, S. C. Cardinale, S. M. Kwasny, L. R. Morin, M. M. Butler, T. J. Opperman, , K. C. Keiler

The paper describes the development of ribosome rescue inhibitors that clear drug-resistant Neisseria gonorrhoeae in vivo through a novel mechanism involving ribosomal conformational changes.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology

The structures of natively assembled clathrin coated vesicles

M. Paraan, J. H. Mendez, S. Sharum, D. Kurtin, H. He, S. M. Stagg

This study determines the structures of natively assembled clathrin coated vesicles in various geometries and explains how adaptor proteins direct the formation of pentagonal and hexagonal faces.

bioRxiv · Jan 28, 2020Biophysics

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

M. Nosrati, D. Dey, A. Mehrani, S. E. Strassler, N. Zelinskaya, E. D. Hoffer, S. M. Stagg, C. M. Dunham, G. L. Conn

This study identifies functionally critical residues in RmtC that distinguish between 30S-binding affinity and 16S rRNA modification through structural and biochemical analysis.

bioRxiv · Oct 3, 2019Biochemistry

Reconstruction of Average Subtracted Tubular Regions (RASTR) Enables Structure Determination of Tubular Filaments by Cryo-EM

P. S. Randolph, S. M. Stagg

This paper introduces RASTR, a method for 3D reconstruction of tubular structures without symmetry assumptions, and evaluates it on simulated and experimental data.

bioRxiv · Sep 18, 2019Biophysics

Throughput and Resolution with a Next Generation Direct Electron Detector

J. H. Mendez, A. Mehrani, P. S. Randolph, S. M. Stagg

This paper evaluates a new direct electron detector (DE64) for cryo-electron microscopy, showing that counting mode provides better reconstruction resolution per unit time despite lower throughput.

bioRxiv · May 3, 2019Biophysics