Author

S. Matoba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:deep learning· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Hoshino· 7 shared Y. Higuchi· 6 shared Y. Kirita· 6 shared D. Motooka· 4 shared J. Takagi· 4 shared N. Ikemura· 4 shared S. Taminishi· 4 shared T. Okamoto· 4 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

A. Hoshino

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney

A. Hoshino, T. Nishiji, N. Ikemura, M. C. Alcantara, Y. Higuchi, Y. Uchio, Y. Kirita, S. Taminishi, Y. Ozaki, D. Motooka, R. Kobayashi, T. Horii, I. Hatada, S. Matoba

This study identifies the Keap1-Nrf2 pathway as a regulator of TGF-β-mediated CTGF expression in fibroblasts, showing that Nrf2 with Ddx54 suppresses profibrotic genes and reduces fibrosis in mouse heart and kidney.

bioRxiv · Nov 9, 2023 · PreprintCell Biology

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system

S. Taminishi, S. Li, Y. Higuchi, Y. Kirita, D. Motooka, Y. Ozaki, T. Arimori, N. Ikemura, Y. Ito, S. Matoba, T. Okamoto, J. Takagi, D. M. Standley, A. Hoshino

The paper develops a DMS platform to analyze SARS-CoV-2 spike mutations, finding that spike expression, not ACE2 affinity, primarily affects infectivity and evolution.

bioRxiv · Jul 17, 2023 · PreprintMicrobiology

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

E. Urano, Y. Itoh, T. Suzuki, T. Sasaki, J.-i. Kishikawa, K. Akamatsu, Y. Higuchi, Y. Sakai, T. Okamura, S. Mitoma, F. Sugihara, A. Takada, M. Kimura, M. Hirose, T. Sasaki, , T. Okamoto

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

bioRxiv · Dec 29, 2022 · PreprintMicrobiology

Deep mutational scanning to predict antibody escape in SARS-CoV-2 Omicron subvariants

M. C. Alcantara, Y. Higuchi, Y. Kirita, S. Matoba, A. Hoshino

This study uses deep mutational scanning to predict antibody escape in SARS-CoV-2 Omicron subvariants, identifying key mutations that confer resistance to bebtelovimab.

bioRxiv · Dec 2, 2022 · PreprintMicrobiology

Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis

Y. Minami, A. Hoshino, Y. Higuchi, M. Hamaguchi, Y. Kaneko, Y. Kirita, S. Taminishi, A. Taruno, M. Fukui, A. Zoltan, S. Matoba

This study identifies lipophagy as a therapeutic approach to prevent NASH progression by promoting lysosomal lipid exocytosis and reducing intracellular fatty acid accumulation.

bioRxiv · Feb 22, 2022 · PreprintCell Biology

Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

N. Ikemura, S. Taminishi, T. Inaba, T. Arimori, D. Motooka, K. Katoh, Y. Kirita, Y. Kirita, S. Li, T. Suzuki, Y. Itoh, Y. Ozaki, S. Nakamura, S. Matoba, D. M. Standley, , A. Hoshino

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

bioRxiv · Dec 22, 2021 · PreprintMicrobiology

High affinity modified ACE2 receptors protect from SARS-CoV-2 infection in hamsters

Y. Higuchi, T. Suzuki, T. Arimori, N. Ikemura, Y. Kirita, E. Ohgitani, O. Mazda, D. Motooka, S. Nakamura, Y. Sakai, Y. Itoh, F. Sugihara, Y. Matsuura, S. Matoba, T. Okamoto, , A. Hoshino

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

bioRxiv · Sep 16, 2020 · PreprintBioengineering