A. Hoshino

The uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling

This study identifies the mechanisms by which recipient cells internalize small extracellular vesicles via paracrine adhesion signaling involving galectin-3, LAMP-2C, and Ca2+-dependent pathways.

Fibroblast Nrf2 inhibits profibrotic transcription with Ddx54 and mitigates pathological fibrosis in the mouse heart and kidney

This study identifies the Keap1-Nrf2 pathway as a regulator of TGF-β-mediated CTGF expression in fibroblasts, showing that Nrf2 with Ddx54 suppresses profibrotic genes and reduces fibrosis in mouse heart and kidney.

Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

This paper introduces a freeze-drying and gaseous nitrogen-based method to improve SEM imaging while preserving fluorescent signals, enabling better visualization of cellular structures and TEV-host interactions.

The Microtubule Severing Protein UNC-45A Counteracts the Microtubule Straightening Effects of Taxol

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system

The paper develops a DMS platform to analyze SARS-CoV-2 spike mutations, finding that spike expression, not ACE2 affinity, primarily affects infectivity and evolution.

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

Deep mutational scanning to predict antibody escape in SARS-CoV-2 Omicron subvariants

This study uses deep mutational scanning to predict antibody escape in SARS-CoV-2 Omicron subvariants, identifying key mutations that confer resistance to bebtelovimab.

CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity

This study uses CRISPR/Cas9 screens to identify RARA and SPNS1 as genetic modifiers of doxorubicin cardiotoxicity, revealing their roles in cell death and drug accumulation.

Genome-wide analysis of R2R3-MYB transcription factors in Japanese morning glory

This study identifies and classifies 126 R2R3-MYB genes in Japanese morning glory, linking their functions to Arabidopsis orthologs and suggesting roles in cell division, anthocyanin biosynthesis, and stress response.

Liver lipophagy ameliorates nonalcoholic steatohepatitis through lysosomal lipid exocytosis

This study identifies lipophagy as a therapeutic approach to prevent NASH progression by promoting lysosomal lipid exocytosis and reducing intracellular fatty acid accumulation.

Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

GLS1 is a Protective Factor Rather than a Molecular Target in ARID1A-Mutated Ovarian Clear Cell Carcinoma

The paper investigates GLS1 expression in ARID1A-mutated ovarian clear cell carcinoma and finds it is not correlated with ARID1A loss and is associated with better clinical outcomes.

High affinity modified ACE2 receptors protect from SARS-CoV-2 infection in hamsters

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

UNC-45A Weakens and Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer

This study identifies endocytosis-related gene polymorphisms in breast cancer and suggests alpha-cyclodextrin as a potential treatment to inhibit metastasis and exosome packaging.