D. M. Standley

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire

The paper shows that ZAP-70 mutations in mice lead to a shift in T cell repertoires, with pathogenic Th17 cells resembling Tregs and contributing to autoimmune arthritis.

Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system

The paper develops a DMS platform to analyze SARS-CoV-2 spike mutations, finding that spike expression, not ACE2 affinity, primarily affects infectivity and evolution.

Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.

The paper reveals how Toxoplasma gondii inactivates Irgb6 through ROP18-mediated phosphorylation, preventing its function in host defense.

Intercellular crosstalk in adult dental pulp is mediated by heparin-binding growth factors Pleiotrophin and Midkine

The paper analyzes single-cell transcriptomes of dental pulp to identify unique gene expression profiles and growth factor-mediated crosstalk between cell types.

CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

Three-dimensional motions of GroEL during substrate protein recognition

The paper uses cryo-EM to study the 3D motions of GroEL during substrate recognition, revealing asymmetric binding and conformational dynamics at near-atomic resolution.

Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep

This study uses ribosome profiling to show that uORFs in Per2 mRNA regulate translation and sleep in mice.

Landscape of infection enhancing antibodies in COVID-19 and healthy donors

This study identifies infection-enhancing antibodies in COVID-19 patients and healthy donors, finding they are more frequent in patients but also present in healthy individuals.

Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant

This paper shows engineered ACE2 neutralizes Omicron and other sarbecoviruses effectively despite its high number of spike mutations.

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

The paper shows the Delta variant can escape NTD antibodies and gain infectivity when specific RBD mutations are present, suggesting the need for updated vaccines.

Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6

This study determines the crystal structures of Irgb6 in GTP-bound and nucleotide-free forms, revealing a unique PVM binding interface that explains its membrane recognition mechanism.

An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 patient antibodies

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

Various miRNAs are involved in efficient HCV replication

This study identifies miRNAs other than miR-122 that support HCV replication in non-hepatic cells by interacting with the viral 5UTR and stabilizing the IRES structure.