Author

M. Kueblbeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:fluorescence / live-cell microscopy· 6 Research Focus:cell type annotation· 4 Approach:microscopy & imaging analysis· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Ellenberg· 8 shared J. Ries· 4 shared M. J. Hossain· 4 shared A. Callegari· 3 shared B. Nijmeijer· 3 shared P. Hoess· 3 shared V. Jimenez Sabinina· 3 shared A. Z. Politi· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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8 shared papersCell Biology

J. Ellenberg

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8 papers

Recent·Most cited

Rapid generation of homozygous fluorescent knock-in human cells using CRISPR/Cas9 genome editing and validation by automated imaging and digital PCR screening

M. Kueblbeck, A. Callegari, B. Serrano-Solano, J. Ellenberg

This paper updates a CRISPR/Cas9 protocol for generating homozygous fluorescent knock-in human cells, improving efficiency and throughput through automation and digital PCR screening.

bioRxiv · Jun 23, 2021 · PreprintCell Biology

A quantitative map of nuclear pore assembly reveals two distinct mechanisms

S. Otsuka, J. O. B. Tempkin, W. Zhang, A. Z. Politi, A. Rybina, M. J. Hossain, M. Kueblbeck, A. Callegari, B. Koch, N. R. Morero, A. Sali, J. Ellenberg

The paper maps nuclear pore complex assembly in human cells, revealing two distinct molecular mechanisms with different orders of component addition.

bioRxiv · May 17, 2021Cell Biology

3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex

V. Jimenez Sabinina, M. J. Hossain, J.-K. Heriche, P. Hoess, B. Nijmeijer, S. Mosalaganti, M. Kueblbeck, A. Callegari, A. Szymborska, M. Beck, J. Ries, J. Ellenberg

The paper uses 3D super-resolution microscopy and computational methods to map the 3D structure of the Nuclear Pore Complex in human cells, revealing variable conformations of its subunits.

bioRxiv · Nov 27, 2020Cell Biology

Photoactivation of silicon rhodamines via a light-induced protonation

M. S. Frei, P. Hoess, M. Lampe, B. Nijmeijer, M. Kueblbeck, J. Ellenberg, J. Ries, S. Pitsch, L. Reymond, K. Johnsson

This paper introduces a new photoactivatable fluorophore that enables live-cell super-resolution microscopy without caging groups or side-products.

bioRxiv · May 4, 2019Biophysics

Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT

T. Schlichthaerle, M. T. Strauss, F. Schueder, A. Auer, B. Nijmeijer, M. Kueblbeck, V. Jimenez Sabinina, J. V. Thevatasan, J. Ries, J. Ellenberg, R. Jungmann

This paper develops a method to directly visualize single nuclear pore complex proteins using DNA-PAINT microscopy with genetically-encoded tags, achieving ~3 nm resolution in human cells.

bioRxiv · Mar 23, 2019Cell Biology

Nuclear pores as versatile reference standards for quantitative superresolution microscopy

J. V. Thevathasan, M. Kahnwald, K. Cieslinski, P. Hoess, S. K. Peneti, M. Reitberger, D. Heid, K. C. Kasuba, S. J. Hoerner, Y. Li, Y.-L. Wu, M. Mund, U. Matti, P. M. Pereira, R. Henriques, , J. Ries

The paper uses genome-edited cell lines with labeled nuclear pore complexes to serve as reference standards for quantitative superresolution microscopy.

bioRxiv · Mar 20, 2019Biophysics

A quantitative map of human Condensins provides new insights into mitotic chromosome architecture

N. Walther, M. J. Hossain, A. Z. Politi, B. Koch, M. Kueblbeck, O. Oedegaard-Fougner, M. Lampe, J. Ellenberg

The paper quantifies Condensin I and II dynamics during mitosis, proposing a three-step loop model for chromosome compaction.

bioRxiv · Mar 22, 2018Cell Biology

Postmitotic Nuclear Pore Assembly Proceeds By Radial Dilation Of Small ER Membrane Openings

S. Otsuka, A. M. Steyer, M. Schorb, J.-K. Heriche, M. J. Hossain, S. Sethi, M. Kueblbeck, Y. Schwab, M. Beck, J. Ellenberg

The paper shows that postmitotic nuclear pore assembly occurs through dilation of ER membrane openings, forming transport channels rapidly.

bioRxiv · Sep 21, 2017Cell Biology