M. J. Hossain

A quantitative map of nuclear pore assembly reveals two distinct mechanisms

The paper maps nuclear pore complex assembly in human cells, revealing two distinct molecular mechanisms with different orders of component addition.

3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex

The paper uses 3D super-resolution microscopy and computational methods to map the 3D structure of the Nuclear Pore Complex in human cells, revealing variable conformations of its subunits.

Non-rodent mammalian zygotes assemble dual spindles despite the presence of paternal centrosomes

This study shows that non-rodent mammalian zygotes, like bovine and human, form two independent spindles around parental genomes despite inherited paternal centrosomes.

Genomic diversity of Escherichia coli isolates from healthy children in rural Gambia

This study sequenced E. coli isolates from healthy children in rural Gambia, finding most diversity comes from immigration rather than within-host evolution.

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

The paper quantifies CTCF and cohesin levels in mammalian cells to improve 3D genome models and provides a method for measuring Halo-tagged proteins.

Dual spindle formation in zygotes keeps parental genomes apart in early mammalian embryos

The paper shows that two spindles form in mammalian zygotes to keep parental genomes apart during the first cleavage.

A quantitative map of human Condensins provides new insights into mitotic chromosome architecture

The paper quantifies Condensin I and II dynamics during mitosis, proposing a three-step loop model for chromosome compaction.

Postmitotic Nuclear Pore Assembly Proceeds By Radial Dilation Of Small ER Membrane Openings

The paper shows that postmitotic nuclear pore assembly occurs through dilation of ER membrane openings, forming transport channels rapidly.