S. Ojima

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

Viruses encode tRNA and anti-retron to evade bacterial immunity

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

Selective bacteriophages reduce the emergence of resistant bacteria in the bacteriophage-antibiotic combination therapy

This study shows that selecting specific bacteriophages in combination with antibiotics can reduce the emergence of resistant bacteria, using Escherichia coli O157:H7 as a model.

Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.