K. S. Kim

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

This study uses holotomography and machine learning to classify functional immune states of human monocytes, achieving high accuracy in identifying hyper-inflammatory and immune-suppressed states.

Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution

This study shows isolation measures during the pandemic selected for SARS-CoV-2 variants with earlier and higher peak viral loads but shorter infection duration.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Pyruvate oxidase as a key determinant of pneumococcal viability during transcytosis across the blood-brain barrier endothelium

This study identifies pyruvate oxidase (SpxB) as critical for pneumococcal survival during transcytosis across the blood-brain barrier by enabling acid tolerance and lysosomal enzyme inactivation.

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule

The paper models how SNP mutations in NPC1 affect filovirus entry efficiency using in vitro experiments and a mathematical model.

Development and Application of a High-Content Virion Display Human GPCR Array

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.