Author

K. Shionoya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

K. Watashi· 6 shared H. Ohashi· 5 shared T. Suzuki· 5 shared S. Iwami· 4 shared S. Iwanami· 4 shared Y. Takahashi· 4 shared D. Akazawa· 3 shared H. Ebihara· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMicrobiology

K. Watashi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents

T. Hishiki, T. Morita, D. Akazawa, H. Ohashi, E.-S. Park, M. Kataoka, J. Mifune, K. Shionoya, K. Tsuchimoto, S. Ojima, A. H. Azam, S. Nakajima, T. Yoshikawa, M. Shimojima, K. Kiga, , K. Watashi

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

bioRxiv · Dec 26, 2022 · PreprintMicrobiology

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

D. Akazawa, H. Ohashi, T. Hishiki, T. Morita, S. Iwanami, K. S. Kim, Y. D. Jeong, E.-S. Park, M. Kataoka, K. Shionoya, J. Mifune, K. Tsuchimoto, S. Ojima, A. H. Azam, S. Nakajima, , K. Watashi

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

N. M. Schmidt, P. A. Wing, R. Peters, R. Brown, H. Wang, L. Swadling, J. Newman, N. Thakur, K. Shionoya, S. B. Morgan, T. S. Hinks, K. Watashi, D. Bailey, S. B. Hansen, M. K. Maini, J. A. McKeating

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

bioRxiv · Apr 12, 2022 · PreprintImmunology

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

H. Ohashi, T. Hishiki, D. Akazawa, K. S. Kim, J. Woo, K. Shionoya, K. Tsuchimoto, S. Iwanami, S. Moriyama, H. Kinoshita, S. Yamada, Y. Kuroda, T. Yamamoto, N. Kishida, S. Watanabe, , K. Watashi

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

bioRxiv · Feb 27, 2022Microbiology

Anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) potency of Mefloquine as an entry inhibitor in vitro

K. Shionoya, M. Yamasaki, S. Iwanami, Y. Ito, S. Fukushi, H. Ohashi, W. Saso, T. Tanaka, S. Aoki, K. Kuramochi, S. Iwami, Y. Takahashi, T. Suzuki, M. Muramatsu, M. Takeda, , K. Watashi

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

bioRxiv · Nov 19, 2020Microbiology

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

H. Ohashi, K. Watashi, W. Saso, K. Shionoya, S. Iwanami, T. Hirokawa, T. Shirai, S. Kanaya, Y. Ito, K. S. Kim, K. Nishioka, S. Ando, K. Ejima, Y. Koizumi, T. Tanaka, , T. Wakita

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

bioRxiv · Apr 14, 2020 · PreprintMicrobiology