Author

S. P. Hunger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:experimental assay· 2

Frequent Co-Authors

C. Chen· 2 shared C.-h. Chen· 2 shared K. Tan· 2 shared P. Gao· 2 shared Y.-y. Ding· 2 shared A. D. Wells· 1 shared A. Felmeister· 1 shared A. Modi· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

C. Chen

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4 papers

Recent·Most cited

Integrative genomics identifies lncRNA regulatory networks across 1,044 pediatric leukemias and extra-cranial solid tumors

A. Modi, G. Lopez, K. L. Conkrite, C. Su, T. C. Leung, S. Ramanan, E. Manduchi, M. E. Johnson, D. Cheung, S. Gadd, J. Zhang, M. A. Smith, J. M. Guidry Auvil, D. S. Gerhard, S. Meshinchi, , S. J. Diskin

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

bioRxiv · Dec 10, 2020 · PreprintCancer Biology

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

C. Chen, W. Yu, F. Alikarami, Q. Qiu, C.-h. Chen, J. Flournoy, P. Gao, Y. Uzun, L. Fang, Y. Yu, Q. Zhu, K. Wang, C. Libbrecht, A. Felmeister, I. Rozich, , K. Tan

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

bioRxiv · Dec 6, 2020 · PreprintCancer Biology

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

H. Yang, H. Zhang, Y. Luan, T. Liu, K. G. Roberts, M.-x. Qian, B. Zhang, W. Yang, V. Perez-Andreu, J. Xu, S. Iyyanki, D. Kuang, S. C. Reshmi, J. Gastier-Foster, C. Smith, , J. J. Yang

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

bioRxiv · Feb 23, 2020 · PreprintCancer Biology

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

B. He, P. Gao, Y.-y. Ding, C.-h. Chen, G. Chen, C. Chen, H. Kim, S. K. Tasian, S. P. Hunger, K. Tan

This study identifies and characterizes noncoding mutations in pediatric cancers using a computational framework and experimental validation, revealing their role in deregulating cis-regulatory landscapes.

bioRxiv · Nov 15, 2019Cancer Biology