S. G. Hansen

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

The paper identifies a gut microbial signature predictive of RhCMV/SIV vaccine efficacy in rhesus macaques using 16S rRNA analysis and compositional data techniques.

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

This study shows that pre-existing CMV immunity in nonhuman primates reduces placental transmission and fetal loss during reinfection compared to primary infection.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

This paper constructs a full-length rhesus cytomegalovirus (RhCMV) by repairing mutations in the 68-1 strain and shows it replicates more effectively in vivo compared to the passaged strain.

Systematic profiling of full-length immunoglobulin and T-cell receptor repertoire diversity in rhesus macaque through long read transcriptome sequencing

This study uses long-read sequencing to profile full-length Ig and TCR repertoires in rhesus macaques, revealing significant diversity missed by traditional methods.

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.