Author

G. Rancati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

C. K. Wong· 3 shared M. Giam· 2 shared A. Ciliberto· 1 shared A. Poti· 1 shared A. Scelfo· 1 shared A. Smogorzewska· 1 shared D. Cimini· 1 shared D. Fachinetti· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

C. K. Wong

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Author profile →

4 papers

Recent·Most cited

Whole-genome duplication shapes the aneuploidy landscape of human cancers

K. Prasad, M. Bloomfield, H. Levi, K. Keuper, S. V. Bernhard, N. C. Baudoin, G. Leor, M. Giam, C. K. Wong, G. Rancati, Z. Storchova, D. Cimini, U. Ben-David

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

bioRxiv · May 5, 2021Cancer Biology

Epistasis, aneuploidy, and gain-of-function mutations underlie the evolution ofresistance to induced microtubule depolymerization

M. Pavani, P. Bonaiuti, E. Chiroli, F. Gross, F. Natali, F. Macaluso, A. Poti, S. Pasqualato, S. Pompei, M. Cosentino Lagomarsino, G. Rancati, D. Szuts, A. Ciliberto

The paper evolves yeast populations with impaired microtubule polymerization and identifies mutations and chromosome duplications that confer resistance to microtubule depolymerizing drugs.

bioRxiv · Oct 7, 2020 · PreprintCell Biology

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

S. Giunta, S. Herve, R. R. White, T. Wilhelm, M. Dumont, A. Scelfo, R. Gamba, C. K. Wong, G. Rancati, A. Smogorzewska, H. Funabiki, D. Fachinetti

This study shows that CENP-A chromatin prevents replication stress at centromeres, reducing structural aneuploidy by safeguarding DNA replication of alpha-satellite repeats.

bioRxiv · Sep 1, 2020Cell Biology

p53 induces senescence in the unstable progeny of aneuploid cells

G. Rancati, M. Giam, C. K. Wong, J. S. Low, M. Sinelli, O. Dreesen

The paper shows that p53 induces senescence in the chromosomally unstable progeny of aneuploid cells, limiting their proliferation and reducing heterogeneity in aneuploid populations.

bioRxiv · Oct 25, 2019Cancer Biology