Author

S. S. Chavan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. J. Tracey· 4 shared T. Tsaava· 3 shared E. H. Chang· 2 shared H. A. Silverman· 2 shared M. E. Addorisio· 2 shared M. Gunasekaran· 2 shared U. Andersson· 2 shared V. A. Pavlov· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersPhysiology

K. J. Tracey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Electrical stimulation of the dorsal motor nucleus of the vagus regulates inflammation without affecting the heart rate

A. Falvey, S. P. Palandira, S. S. Chavan, M. Brines, K. J. Tracey, V. A. Pavlov

This study shows that electrical stimulation of the dorsal motor nucleus of the vagus reduces inflammation in endotoxemia and sepsis without affecting heart rate.

bioRxiv · May 17, 2023 · PreprintPhysiology

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

A. Quintanal-Villalonga, H. Taniguchi, M. A. Hasan, F. Meng, F. Uddin, M. Donoghue, H. H. Won, S. S. Chavan, J. M. Chan, M. Ciampricotti, A. Chow, M. Offin, J. C. Chang, J. Ray-Kirton, J. Egger, , T. Sen

The paper identifies molecular mechanisms of neuroendocrine transformation in lung cancer using multi-omic analysis of tumors and clinical samples.

bioRxiv · Dec 2, 2020 · PreprintCancer Biology

Serum cytokine levels are modulated by specific frequencies, amplitudes, and pulse widths of vagus nerve stimulation

T. Tsaava, T. Datta-Chaudhuri, M. E. Addorisio, E. B. Masi, H. A. Silverman, J. E. Newman, G. H. Imperato, C. E. Bouton, K. J. Tracey, S. S. Chavan, E. H. Chang

This study shows that specific electrical stimulation parameters of the vagus nerve can modulate serum cytokine levels in healthy mice without inducing inflammation.

bioRxiv · Jan 8, 2020 · PreprintImmunology

Antibody responses to immunization require sensory neurons

A. Tynan, T. Tsaava, M. Gunasekaran, I. Snee, T. Mak, P. Olofsson, U. Andersson, S. S. Chavan, K. J. Tracey

This study shows that TRPV1-expressing sensory neurons are required for antibody responses to novel antigens and that stimulating these neurons enhances antibody production.

bioRxiv · Nov 30, 2019 · PreprintImmunology

Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

H. A. Silverman, M. Gunasekaran, E. H. Chang, Q. Chang, M. E. Addorisio, A. Stiegler, A. M. Kressel, J. H. Li, T. Tsaava, T. S. Huerta, V. A. Pavlov, U. Andersson, S. S. Chavan, K. J. Tracey

This study identifies TRPA1 in vagus neurons as essential for detecting IL-1β to initiate the inflammatory reflex, reducing inflammation and improving survival in sepsis.

bioRxiv · Nov 4, 2019 · PreprintPhysiology