K. J. Tracey

Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia

This study finds higher plasma lipopolysaccharide-binding protein and pro-inflammatory mediators in overweight women, suggesting subclinical endotoxemia and inflammation linked to cardiovascular risk.

Electrical stimulation of the dorsal motor nucleus of the vagus regulates inflammation without affecting the heart rate

This study shows that electrical stimulation of the dorsal motor nucleus of the vagus reduces inflammation in endotoxemia and sepsis without affecting heart rate.

Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes

The paper demonstrates that focused ultrasound activation of the hepatic neural plexus restores glucose homeostasis in diabetes models across multiple species.

Monoclonal Antibodies Capable of Binding SARS-CoV-2 Spike Protein Receptor Binding Motif Specifically Prevent GM-CSF Induction.

This study identifies two monoclonal antibodies that bind SARS-CoV-2 spike protein RBM and inhibit GM-CSF induction in immune cells.

Serum cytokine levels are modulated by specific frequencies, amplitudes, and pulse widths of vagus nerve stimulation

This study shows that specific electrical stimulation parameters of the vagus nerve can modulate serum cytokine levels in healthy mice without inducing inflammation.

Antibody responses to immunization require sensory neurons

This study shows that TRPV1-expressing sensory neurons are required for antibody responses to novel antigens and that stimulating these neurons enhances antibody production.

Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

This study identifies TRPA1 in vagus neurons as essential for detecting IL-1β to initiate the inflammatory reflex, reducing inflammation and improving survival in sepsis.