E. H. Chang

Flexible IrOx Neural Electrode for Mouse Vagus Nerve Stimulation

This paper develops and evaluates a flexible IrOx electrode for mouse vagus nerve stimulation, showing it remains functional under high stimulation and induces reliable physiological responses.

High-Stability Polyimide-based Flexible Electrodes with IrOx to Interface the Mouse Vagus Nerve

This paper develops flexible polyimide-based electrodes with IrOx for interfacing mouse vagus nerve, showing stable performance and efficacy in stimulating physiological responses.

An implant for long-term cervical vagus nerve stimulation in mice

This paper develops a long-term vagus nerve stimulation implant in mice and demonstrates its effectiveness in reducing inflammation over 4 weeks.

Serum cytokine levels are modulated by specific frequencies, amplitudes, and pulse widths of vagus nerve stimulation

This study shows that specific electrical stimulation parameters of the vagus nerve can modulate serum cytokine levels in healthy mice without inducing inflammation.

Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

This study identifies TRPA1 in vagus neurons as essential for detecting IL-1β to initiate the inflammatory reflex, reducing inflammation and improving survival in sepsis.

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.