I. Kim

Whole-body PET imaging of SIV using anti-Env probes fails to reveal regions of specific uptake in rhesus macaques

This study evaluates two anti-gp120 antibodies for immunoPET imaging of SIV in rhesus macaques and finds no specific uptake, suggesting inadequate binding potential for in vivo imaging.

Bred for affection: The canine anterior ectosylvian gyrus responds selectively to social reinforcement

The paper implants a neuromodulation platform in a beagle to study brain activity, finding the anterior ectosylvian gyrus responds selectively to social reinforcement, suggesting speech understanding may evolve from social brain structures.

Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of influenza A virus

This study analyzes how mutations in the NS1 protein of influenza A virus rewired allosteric and epistatic networks, enhancing its binding affinity to p85β.

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function

The paper identifies multiple genetic variants at the SLC30A8 locus that influence enhancer activity and β cell function, with some variants affecting gene expression and insulin secretion.

A self-renewing biomimetic skeletal muscle construct engineered using induced myogenic progenitor cells

This paper develops a self-renewing biomimetic skeletal muscle construct using induced myogenic progenitor cells that recapitulates myogenic differentiation and repair.

The Ralstonia pseudosolanacearum effector RipE1 is recognized at the plasma membrane by NbPtr1, Nicotiana benthamiana homolog of Pseudomonas tomato race 1.

This study identifies NbPtr1 as the receptor recognizing the Ralstonia pseudosolanacearum effector RipE1 in Nicotiana benthamiana, showing membrane association and polymorphism in recognition.

The energy landscape reshaped by strain-specific mutations underlies the long-range epistasis in NS1 evolution of influenza A virus

The paper investigates how strain-specific mutations in the NS1 protein of influenza A virus reshape the energy landscape, leading to long-range epistasis.

Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells

This study identifies distinct molecular trajectories in fibroblast reprogramming to myogenic progenitor cells versus myogenic transdifferentiation, highlighting Notch pathway activation as critical for iMPC formation.

Distributed brain co-processor for tracking electrophysiology and behavior during electrical brain stimulation

The paper describes a distributed brain co-processor that integrates electrophysiology and behavioral tracking during electrical brain stimulation in humans and canines.

Regeneration of a Full-Thickness Defect in Rotator Cuff Tendon with Umbilical Cord-Derived Mesenchymal Stem Cells in a Rat Model

This study evaluates the efficacy of umbilical cord-derived mesenchymal stem cells (UC MSCs) in regenerating full-thickness rotator cuff defects in a rat model, showing improvements in macroscopic, histological, and biomechanical outcomes.

Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles

This study shows that suppression gene drives in spatial models can lead to unstable persistence of both drive and wild-type alleles due to chasing dynamics.