Y. Barral

A protein condensation network contextualises cell fate decisions

The paper identifies a protein condensation network in yeast that integrates internal and external signals to regulate cell fate decisions during senescence and pheromone response.

Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.

Fission-independent compartmentalization of mitochondria during budding yeast cell division

This study shows mitochondria are compartmentalized at the bud neck in budding yeast through fission-independent diffusion barriers regulated by spatial cues and RTG signaling.

High interaction valency ensures cohesion and persistence of a microtubule +TIP body at the plus-end of a single specialized microtubule in yeast

The paper investigates the Kar9 network in yeast, showing it forms a multivalent, liquid-like condensate at microtubule tips that persists during growth and shrinkage and functions as a mechanical coupling device.

Role of mitotic diffusion barriers in regulating the asymmetric division of activated CD8 T cells

This study shows that diffusion barriers in the ER membrane regulate metabolic and plasma membrane asymmetry in CD8 T cells during their first division, influencing whether they become memory or effector cells.

Specialization of chromatin-bound nuclear pore complexes promotes yeast aging

This study shows that DNA circles in yeast cells alter NPC composition, leading to aging by triggering NPC specialization.

A mechanism to prevent transformation of the Whi3 mnemon into a prion.

This study identifies how Whi3mnem, a memory-like protein in yeast, remains stable in mother cells but is not inherited by daughter cells through ER membrane anchoring and diffusion barriers.