Shell protein composition specified by NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles
H. Takakuwa, T. Yamazaki, S. Souquere, S. Adachi, H. Yoshino, N. Fujiwara, T. Yamamoto, N. Tohru, S. Nakagawa, G. Pierron, T. Hirose
The paper identifies how NEAT1 domains specify shell protein composition in paraspeckles, enabling their independence from nuclear speckles through phase separation.
bioRxiv · May 21, 2023 · PreprintCell Biology