T. Yamazaki

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

NMR analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria

The paper determines the dimeric structure of VanX using NMR and identifies a monomeric form for inhibitor screening.

Shell protein composition specified by NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles

The paper identifies how NEAT1 domains specify shell protein composition in paraspeckles, enabling their independence from nuclear speckles through phase separation.

Biophysical analysis of Gaussia Luciferase bioluminescence mechanisms using a non-oxidizable coelenterazine.

The paper investigates the bioluminescence mechanism of Gaussia Luciferase using azacoelenterazine, revealing the role of salt and monovalent anions and structural changes in catalysis.

Cell-surface protein YwfG of Lactococcus lactis binds to α-1,2-linked mannose

This study identifies YwfG as a cell-surface protein in Lactococcus lactis that binds α-1,2-linked mannose, revealing its role in interactions with yeast cells.

Lateral surface pressure generated by nascent ribosomal RNA suppresses growth of fibrillar centers in the nucleolus

The paper develops a theoretical model explaining how nascent pre-rRNAs suppress fibrillar center growth in nucleoli through lateral pressure, supported by experimental validation.

Triblock copolymer micelle model of spherical paraspeckles

The paper models paraspeckles as triblock copolymer micelles and predicts structural changes based on arcRNA block length, validated by experiments.

Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR

This paper determines the solution structure of Gaussia Luciferase using NMR and identifies a potential coelenterazine binding cavity involved in bioluminescence.

Erythropoietin production?by the kidney and the liver in response to severe hypoxia evaluated by Western blotting with deglycosylation

This study develops a Western blot method with deglycosylation to detect Epo and ESAs in urine and plasma, showing the kidney as the main site of Epo production under hypoxia.