T. Hirose

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss.

This study shows that BET inhibition rescues ciliogenesis and reduces pancreatitis-induced damage in mice with Par3 loss.

Neutralizing antibody responses and cellular responses against severe acute respiratory syndrome coronavirus 2 omicron subvariant BA.5 after an mRNA severe acute respiratory syndrome coronavirus 2 vaccine dose in kidney transplant recipients

This study evaluates antibody and cellular immune responses in kidney transplant recipients after three mRNA vaccine doses, finding lower neutralizing titers and T cell responses compared to healthy controls.

Shell protein composition specified by NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles

The paper identifies how NEAT1 domains specify shell protein composition in paraspeckles, enabling their independence from nuclear speckles through phase separation.

The early macrophage response to pathogens requires dynamic regulation of the nuclear paraspeckle

This paper shows that the nuclear paraspeckle dynamically regulates inflammatory gene expression in macrophages, essential for controlling pathogen replication.

Lateral surface pressure generated by nascent ribosomal RNA suppresses growth of fibrillar centers in the nucleolus

The paper develops a theoretical model explaining how nascent pre-rRNAs suppress fibrillar center growth in nucleoli through lateral pressure, supported by experimental validation.

Creation of X-linked Alport Syndrome Rat Model with Col4a5 Deficiency

This study creates a novel Alport syndrome rat model with Col4a5 deficiency to better understand renal disease mechanisms and therapeutic targets.

Triblock copolymer micelle model of spherical paraspeckles

The paper models paraspeckles as triblock copolymer micelles and predicts structural changes based on arcRNA block length, validated by experiments.

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.