Author

R. M. Whan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2

Frequent Co-Authors

E. Pandzic· 4 shared A. Capraro· 2 shared A. Jaffe· 2 shared L. Zhong· 2 shared M. Kavallaris· 2 shared S. A. Waters· 2 shared S. L. Wong· 2 shared A. Adhikari· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCancer Biology

E. Pandzic

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The parasitic lifestyle of an archaeal symbiont

J. N. Hamm, Y. Liao, A. von Kügelgen, N. Dombrowski, E. Landers, C. Brownlee, E. M. V. Johansson, R. M. Whan, M. A. B. Baker, B. Baum, T. A. M. Bharat, I. G. Duggin, A. Spang, R. Cavicchioli

This study identifies a parasitic lifestyle in a DPANN archaeon that causes host cell lysis, suggesting a predatory-like interaction similar to viruses.

bioRxiv · Feb 24, 2023Microbiology

βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer

J. Kokkinos, G. Sharbeen, R. M. C. Ignacio, E. Pandzic, J. Youkhana, C. Boyer, K. S. Haghighi, M. Gunawarman, D. Goldstein, V. Gebski, M. Pajic, O. Pitiyarachchi, M. E. Davis, G. Schulstad, O. S. M. Arkell, , P. A. Phillips

This study identifies βIII-tubulin as a suppressor of extrinsic apoptosis in pancreatic cancer, showing that its silencing enhances sensitivity to death signals and reduces tumor progression.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Spatial-temporal analysis of nanoparticles in live tumor spheroids impacted by cell origin and density

A. Ahmed-Cox, E. Pandzic, S. T. Johnston, C. Heu, J. B. McGhee, F. M. Mansfeld, E. J. Crampin, T. P. Davis, R. M. Whan, M. Kavallaris

This paper develops a platform to analyze nanoparticle uptake in 3D tumor spheroids, showing uptake inversely relates to particle size and varies with cell type and spheroid density.

bioRxiv · Oct 26, 2021 · PreprintBioengineering

Ageing impairs the airway epithelium defence response to SARS-CoV-2

A. Capraro, S. L. Wong, A. Adhikari, K. M. Allan, H. R. Patel, L. Zhong, M. Raftery, A. Jaffe, M. Yeang, A. Aggarwal, L. Wu, E. Pandzic, R. M. Whan, S. Turville, O. Vittorio, , S. A. Waters

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

bioRxiv · Apr 5, 2021 · PreprintImmunology

Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model

C. K. Hewson, A. Capraro, S. L. Wong, E. Pandzic, B. S. M. Fernando, N. T. Awatade, L. Zhong, G. Hart-Smith, R. M. Whan, S. R. Thomas, A. Jaffe, W. J. Bridge, S. A. Waters

This study shows that γ-glutamylcysteine (GGC) reduces LPS-induced oxidative stress and improves cell viability in a cystic fibrosis model.

bioRxiv · May 27, 2020Cell Biology