Author

S. T. Smale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

G. Yeh· 2 shared A. B. Chang· 1 shared A. Daly· 1 shared A. E. Daly· 1 shared A. Sagasti· 1 shared B. D. Redelings· 1 shared B. R. Bloom· 1 shared B. Venkatesh· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

G. Yeh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

A. E. Daly, A. B. Chang, P. Purbey, K. J. Williams, G. Yeh, S. Li, S. D. Pope, B. Venkatesh, B. D. Redelings, S. Li, K. Nguyen, J. Rodriguez, K. Jorgensen, T. Siggers, L. Chen, S. T. Smale

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

Nature Immunology · Apr 30, 2025Peer-reviewedImmunology

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway

A. Daly, G. Yeh, S. Soltero, S. T. Smale

The paper identifies a p50-IκBζ pathway that selectively activates immunoregulatory genes in TLR4-stimulated macrophages, contributing to differential responses compared to TNFR stimulation.

bioRxiv · Jan 23, 2024Immunology

A Macrophage Response To Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage In Leprosy

C. A. Madigan, C. Cambier, K. M. Kelly-Scumpia, P. O. Scumpia, T.-Y. Cheng, J. Zailaa, B. R. Bloom, D. B. Moody, S. T. Smale, A. Sagasti, R. L. Modlin, L. Ramakrishnan

The paper shows that M. leprae's PGL-1 toxin triggers macrophages to damage nerves by inducing nitric oxide, leading to axon demyelination in leprosy.

bioRxiv · Apr 17, 2017Microbiology