Author

T.-Y. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Immunology· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

D. B. Moody· 5 shared B. Moody· 4 shared A. Jeucken· 3 shared B. Poolman· 3 shared H. R. Sikkema· 3 shared J. van't Klooster· 3 shared C. Cambier· 2 shared I. van Rhijn· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

D. B. Moody

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Bioorthogonal metabolic labeling of the virulence factor phenolic glycolipid in mycobacteria

L. E. Guzman, C. Cambier, T.-Y. Cheng, K. F. Naqvi, M. U. Shiloh, D. B. Moody, C. Bertozzi

The paper develops a method to image phenolic glycolipid (PGL) in mycobacteria using bioorthogonal metabolic labeling and demonstrates its application in studying PGL dynamics.

bioRxiv · Nov 28, 2023Biochemistry

Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to Mycobacterium tuberculosis infection

M. C. Harris, H. E. Gary, S. K. Cooper, D. Ackart, J. E. DiLisio, R. J. Basaraba, T.-Y. Cheng, I. van Rhijn, D. B. Moody, B. K. Podell

This study investigates CD1b-restricted immunity to Mycobacterium tuberculosis in guinea pigs, showing transient CD1b upregulation during infection and its role in pulmonary and extrapulmonary immune responses.

bioRxiv · May 23, 2023 · PreprintImmunology

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

H. Faust, T.-Y. Cheng, I. Korsunsky, G. F. M. Watts, S. T. Gal-Oz, W. Trim, K. Kongthong, A. H. Jonsson, D. P. Simmons, F. Zhang, R. Padera, S. Chubinskaya, Accelerating Medicines Partnership Program, K. Wei, S. Raychaudhuri, , M. B. Brenner

The paper shows adipocytes regulate fibroblast function through cortisol signaling, and their loss leads to fibroblast dysfunction in inflammatory diseases.

bioRxiv · May 16, 2023Cell Biology

Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early M. tuberculosis infection

B. S. Zha, L. Desvignes, T. Fergus, A. Cornelius, T.-Y. Cheng, D. B. Moody, J. D. Ernst

This study compares early infection dynamics of two M. tuberculosis strains, showing strain-specific differences in bacterial spread and immune activation.

bioRxiv · May 10, 2022Immunology

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

C. F. Almeida, D. Smith, T.-Y. Cheng, C. Harpur, E. Batleska, T. Nguyen, T. Hilmenyuk, C. V. Nguyen-Robertson, S. J. Reddiex, I. Van Rhijn, J. Rossjohn, A. P. Uldrich, B. Moody, S. J. Williams, D. G. Pellicci, D. I. Godfrey

This study identifies benzofuran sulfonates and small self-lipid antigens as activators of type II NKT cells via CD1d, revealing non-lipidic small molecules that trigger CD1d-restricted NKT cell responses.

bioRxiv · Mar 5, 2021Immunology

Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins

J. van't Klooster, T.-Y. Cheng, H. R. Sikkema, A. Jeucken, B. Moody, B. Poolman

The paper investigates periprotein lipidomes in yeast membrane microdomains, finding localized lipid differences that suggest a disordered environment for protein function.

bioRxiv · Mar 31, 2020Biochemistry

Membrane lipid requirements of the lysine transporter Lyp1 from Saccharomyces cerevisiae

B. Poolman, J. van't Klooster, T.-Y. Cheng, H. R. Sikkema, A. Jeucken, D. B. Moody

The paper identifies essential membrane lipids for the function of the yeast lysine transporter Lyp1 and proposes a model for lipid-protein interactions.

bioRxiv · Mar 27, 2020Biochemistry

Periprotein membrane lipidomics and the role of lipids in transporter function in yeast

J. van't Klooster, T.-Y. Cheng, H. R. Sikkema, A. Jeucken, B. Moody, B. Poolman

The paper investigates lipid composition in yeast plasma membrane microdomains and identifies lipid requirements for transporter function.

bioRxiv · Jan 12, 2020 · PreprintBiochemistry

A Macrophage Response To Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage In Leprosy

C. A. Madigan, C. Cambier, K. M. Kelly-Scumpia, P. O. Scumpia, T.-Y. Cheng, J. Zailaa, B. R. Bloom, D. B. Moody, S. T. Smale, A. Sagasti, R. L. Modlin, L. Ramakrishnan

The paper shows that M. leprae's PGL-1 toxin triggers macrophages to damage nerves by inducing nitric oxide, leading to axon demyelination in leprosy.

bioRxiv · Apr 17, 2017Microbiology