Author

R. L. Modlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

B. R. Bloom· 3 shared F. Ma· 3 shared J. E. Gudjonsson· 3 shared L. C. Tsoi· 3 shared M. Pellegrini· 3 shared P. R. Andrade· 3 shared A. K. Shalek· 2 shared B. Bryson· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

B. R. Bloom

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Non-lesional and Lesional Lupus Skin Share Inflammatory Phenotypes that Drive Activation of CD16+ Dendritic Cells

A. C. Billi, F. Ma, O. Plazyo, M. Gharaee-Kermani, R. Wasikowski, G. A. Hile, X. Xing, C. M. Yee, S. M. Rizvi, M. P. Maz, F. Wen, L. C. Tsoi, M. Pellegrini, R. L. Modlin, J. E. Gudjonsson, J. M. Kahlenberg

The paper compares non-lesional and lesional lupus skin to show they share inflammatory features that activate CD16+ dendritic cells.

bioRxiv · Sep 17, 2021 · PreprintImmunology

Putative Pseudolysogeny-Dependent Phage Gene Implicated in the Superinfection Resistance of Cutibacterium acnes

S. Wottrich, S. Mendonca, C. Safarpour, C. Nguyen, L. J. Marinelli, R. L. Modlin, J. Moberg Parker

The paper identifies a phage gene involved in superinfection resistance of C. acnes through pseudolysogeny.

bioRxiv · Dec 15, 2020Microbiology

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

F. Ma, T. K. Hughes, R. M. B. Teles, P. R. Andrade, B. J. d. A. Silva, O. Plazyo, L. C. Tsoi, T. Do, M. H. Wadsworth, A. Oulee, M. T. Ochoa, E. N. Sarno, M. L. Iruela-Arispe, B. Bryson, A. K. Shalek, , R. L. Modlin

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

T. K. Hughes, M. H. Wadsworth, T. M. Gierahn, T. Do, D. Weiss, P. R. Andrade, F. Ma, B. J. de Andrade Silva, S. Shao, L. C. Tsoi, J. Ordovas-Montanes, J. E. Gudjonsson, R. L. Modlin, J. C. Love, A. K. Shalek

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.

bioRxiv · Jul 2, 2019 · PreprintImmunology

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

D. Montoya, P. R. Andrade, B. J. A. Silva, R. M. B. Teles, B. Bryson, S. Sadanand, T. Noel, J. Lu, E. Sarno, K. B. Arnvig, D. Young, R. Lahiri, D. L. Williams, S. Fortune, B. R. Bloom, , R. L. Modlin

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

bioRxiv · Jun 22, 2018Microbiology

A Macrophage Response To Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage In Leprosy

C. A. Madigan, C. Cambier, K. M. Kelly-Scumpia, P. O. Scumpia, T.-Y. Cheng, J. Zailaa, B. R. Bloom, D. B. Moody, S. T. Smale, A. Sagasti, R. L. Modlin, L. Ramakrishnan

The paper shows that M. leprae's PGL-1 toxin triggers macrophages to damage nerves by inducing nitric oxide, leading to axon demyelination in leprosy.

bioRxiv · Apr 17, 2017Microbiology