Author

B. R. Bloom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

R. L. Modlin· 3 shared B. Bryson· 2 shared M. Pellegrini· 2 shared P. R. Andrade· 2 shared R. M. B. Teles· 2 shared A. K. Shalek· 1 shared A. Oulee· 1 shared A. Sagasti· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMicrobiology

R. L. Modlin

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Author profile →

3 papers

Recent·Most cited

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

F. Ma, T. K. Hughes, R. M. B. Teles, P. R. Andrade, B. J. d. A. Silva, O. Plazyo, L. C. Tsoi, T. Do, M. H. Wadsworth, A. Oulee, M. T. Ochoa, E. N. Sarno, M. L. Iruela-Arispe, B. Bryson, A. K. Shalek, , R. L. Modlin

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

bioRxiv · Dec 1, 2020 · PreprintImmunology

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

D. Montoya, P. R. Andrade, B. J. A. Silva, R. M. B. Teles, B. Bryson, S. Sadanand, T. Noel, J. Lu, E. Sarno, K. B. Arnvig, D. Young, R. Lahiri, D. L. Williams, S. Fortune, B. R. Bloom, , R. L. Modlin

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

bioRxiv · Jun 22, 2018Microbiology

A Macrophage Response To Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage In Leprosy

C. A. Madigan, C. Cambier, K. M. Kelly-Scumpia, P. O. Scumpia, T.-Y. Cheng, J. Zailaa, B. R. Bloom, D. B. Moody, S. T. Smale, A. Sagasti, R. L. Modlin, L. Ramakrishnan

The paper shows that M. leprae's PGL-1 toxin triggers macrophages to damage nerves by inducing nitric oxide, leading to axon demyelination in leprosy.

bioRxiv · Apr 17, 2017Microbiology