Author

D. B. Moody

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Immunology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Assay:flow cytometry· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

T.-Y. Cheng· 5 shared J. A. Mayfield· 3 shared C. Cambier· 2 shared D. C. Young· 2 shared Y. S. Morita· 2 shared A. Cornelius· 1 shared A. D. Huang· 1 shared A. Jeucken· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

T.-Y. Cheng

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Bioorthogonal metabolic labeling of the virulence factor phenolic glycolipid in mycobacteria

L. E. Guzman, C. Cambier, T.-Y. Cheng, K. F. Naqvi, M. U. Shiloh, D. B. Moody, C. Bertozzi

The paper develops a method to image phenolic glycolipid (PGL) in mycobacteria using bioorthogonal metabolic labeling and demonstrates its application in studying PGL dynamics.

bioRxiv · Nov 28, 2023Biochemistry

Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to Mycobacterium tuberculosis infection

M. C. Harris, H. E. Gary, S. K. Cooper, D. Ackart, J. E. DiLisio, R. J. Basaraba, T.-Y. Cheng, I. van Rhijn, D. B. Moody, B. K. Podell

This study investigates CD1b-restricted immunity to Mycobacterium tuberculosis in guinea pigs, showing transient CD1b upregulation during infection and its role in pulmonary and extrapulmonary immune responses.

bioRxiv · May 23, 2023 · PreprintImmunology

Genetic and lipidomic identification of tuberculostearic acid as a controller of mycobacterial membrane compartmentalization

M. Prithviraj, T. Kado, J. A. Mayfield, D. C. Young, A. D. Huang, D. Motooka, S. Nakamura, M. S. Siegrist, D. B. Moody, Y. S. Morita

The paper identifies tuberculostearic acid (TBSA) as a key lipid controlled by the gene cfa, which regulates membrane compartmentalization in Mycobacterium smegmatis.

bioRxiv · Aug 17, 2022 · PreprintMicrobiology

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Bacterial strain-dependent dissociation of cell recruitment and cell-to-cell spread in early M. tuberculosis infection

B. S. Zha, L. Desvignes, T. Fergus, A. Cornelius, T.-Y. Cheng, D. B. Moody, J. D. Ernst

This study compares early infection dynamics of two M. tuberculosis strains, showing strain-specific differences in bacterial spread and immune activation.

bioRxiv · May 10, 2022Immunology

CD36 family members are TCR-independent ligands for CD1 antigen-presentingmolecules

N. A. Gherardin, S. J. Redmond, H. E. McWilliam, C. F. Almeida, K. H. Gourley, R. Seneviratna, S. Li, R. De Rose, C. V. Nguyen-Robertson, S. Su, M. Ritchie, J. A. Villadangos, D. B. Moody, D. G. Pellicci, A. P. Uldrich, D. I. Godfrey

The paper identifies CD36 family members as ligands for CD1 molecules and shows that blocking this interaction enables accurate identification of CD1-restricted T cells.

bioRxiv · Mar 10, 2021Immunology

Membrane lipid requirements of the lysine transporter Lyp1 from Saccharomyces cerevisiae

B. Poolman, J. van't Klooster, T.-Y. Cheng, H. R. Sikkema, A. Jeucken, D. B. Moody

The paper identifies essential membrane lipids for the function of the yeast lysine transporter Lyp1 and proposes a model for lipid-protein interactions.

bioRxiv · Mar 27, 2020Biochemistry

Demethylmenaquinone methyl transferase is a membrane domain-associated protein essential for menaquinone homeostasis in Mycobacterium smegmatis

J. Puffal, J. A. Mayfield, D. B. Moody, Y. S. Morita

This study identifies MenG as an essential enzyme for menaquinone homeostasis in Mycobacterium smegmatis, showing its association with the intracellular membrane domain and its role in regulating menaquinone levels.

bioRxiv · Oct 25, 2018Microbiology

A Macrophage Response To Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage In Leprosy

C. A. Madigan, C. Cambier, K. M. Kelly-Scumpia, P. O. Scumpia, T.-Y. Cheng, J. Zailaa, B. R. Bloom, D. B. Moody, S. T. Smale, A. Sagasti, R. L. Modlin, L. Ramakrishnan

The paper shows that M. leprae's PGL-1 toxin triggers macrophages to damage nerves by inducing nitric oxide, leading to axon demyelination in leprosy.

bioRxiv · Apr 17, 2017Microbiology