S. V. Gordon

Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses

This study shows that IL-4 and IL-13 activation of macrophages induces protective innate memory against mycobacterial infection through enhanced OXPHOS-driven pro-inflammatory responses.

Mycobacterial infection of precision cut lung slices reveals that the type 1 interferon pathway is locally induced by Mycobacterium bovis but not M. tuberculosis in different cattle breeds

The paper uses precision-cut lung slices to compare immune responses to Mycobacterium bovis and M. tuberculosis in two cattle breeds, finding that M. bovis induces the type I interferon pathway while M. tuberculosis does not.

Phylodynamic analysis of an emergent Mycobacterium bovis outbreak in an area with no previously known wildlife infections

The paper analyzes an M. bovis outbreak in cattle and badgers using mathematical modeling, machine learning, and Bayesian methods, finding a single introduction from Northern Ireland and two-phase transmission dynamics.

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.

Updated functional annotation of the Mycobacterium bovis AF2122/97 reference genome.

The paper updates the functional annotation of the Mycobacterium bovis AF2122/97 genome by adding 616 new protein identifications and 69 new gene names based on orthologous information from M. tuberculosis H37Rv.

Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle

This study infects cattle with M. tuberculosis isolates to show their attenuation compared to M. bovis and explores biomarkers of disease progression using RNA-Seq.