Author

S. Withoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

I. H. Jonkers· 5 shared C. Wijmenga· 4 shared A. D. Ramirez-Sanchez· 2 shared A. Zhernakova· 2 shared J. Fu· 2 shared J. Mooiweer· 2 shared L. Franke· 2 shared R. J. Barrett· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersCell Biology

I. H. Jonkers

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

R. Moerkens, J. Mooiweer, E. Smits, M. Berg, A. D. Ramirez Sanchez, R. Modderman, J. Puschhof, C. Pleguezuelos-Manzano, R. J. Barrett, C. Wijmenga, I. H. Jonkers, S. Withoff

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

bioRxiv · Jun 30, 2024 · PreprintCell Biology

High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation

J. Slager, H. L. Simpson, R. Gacesa, L. Chen, I. L. Tan, J. Gelderloos, A. Maatman, C. Wijmenga, A. Zhernakova, J. Fu, R. K. Weersma, G. Gonera, I. H. Jonkers, S. Withoff

This study analyzes the gut microbiome of treated coeliac disease patients at strain level, revealing increased interindividual variation and specific microbial associations.

bioRxiv · Mar 8, 2024Microbiology

Gene expression and eQTL analysis reflect the heterogeneity in the inflammatory status of the duodenal epithelial lining in coeliac disease

A. D. Ramirez-Sanchez, S. Zühlke, R. Aguirre-Gamboa, M. Vochteloo, L. Franke, K. E. A. Lundin, S. Withoff, I. H. Jonkers

This study identifies gene expression patterns and eQTLs in duodenal epithelial lining of coeliac disease patients that reflect inflammation status and disease condition.

bioRxiv · Feb 29, 2024Immunology

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

R. Moerkens, J. Mooiweer, A. D. Ramirez-Sanchez, R. Oelen, L. Franke, C. Wijmenga, R. J. Barrett, I. H. Jonkers, S. Withoff

This paper develops a hiPSC-derived intestine-on-chip system that mimics the human small intestine's epithelial, mesenchymal, and neural composition and function.

bioRxiv · Jan 4, 2024Cell Biology

Genetic, environmental and intrinsic determinants of the human antibody epitope repertoire

S. Andreu-Sanchez, A. R. Bourgonje, T. Vogl, A. Kurilshikov, S. Leviatan, A. J. Ruiz Moreno, S. Hu, T. Sinha, A. Vich Vila, S. Klompus, I. Kalka, K. de Leeuw, S. Arends, I. H. Jonkers, S. Withoff, , A. Zhernakova

This study uses PhIP-Seq to analyze antibody repertoires in 1,443 individuals, showing genetic and environmental factors influence antibody diversity and phenotype associations.

bioRxiv · Dec 7, 2021Immunology