T. Vogl

Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.

Gαq modulates the energy metabolism of osteoclasts

This study shows that Gαq enhances osteoclast energy metabolism by promoting glycolysis and mitochondrial respiration, contributing to increased bone resorption.

In-depth characterization of the serum antibody epitope repertoire in inflammatory bowel disease using phage-displayed immunoprecipitation sequencing

This study identifies distinct antibody epitope repertoires in IBD patients using PhIP-seq, revealing differentially abundant antibodies associated with disease subtypes and features.

Genetic, environmental and intrinsic determinants of the human antibody epitope repertoire

This study uses PhIP-Seq to analyze antibody repertoires in 1,443 individuals, showing genetic and environmental factors influence antibody diversity and phenotype associations.

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100A8 and S100A9

This study identifies C/EBPδ as a key regulator of S100A8 and S100A9 expression through epigenetic mechanisms in monocytes, with implications for inflammatory diseases.

2.5D Tractions in monocytes reveal mesoscale mechanics of podosomes during substrate indenting cell protrusion

This study examines mesoscale mechanical forces in podosome clusters of monocytes, revealing that collective behavior arises from network contraction and buckling, not just individual podosome mechanics.

Endothelial basement membrane laminins as an environmental cue in monocyte differentiation to macrophages.

This study shows that endothelial basement membrane laminins 411 and 511 influence monocyte differentiation to macrophages by modulating migration and integrin profiles.

Calprotectin modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

This study shows that S100A8/A9 modulates inflammatory collateral tissue damage and fungal clearance during systemic candidiasis, with paquinimod reducing ICTD.