Author

S. X. Sun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Approach:mechanistic / dynamical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Y. Li· 4 shared K. Konstantopoulos· 3 shared Y. Wu· 3 shared M. I. Choudhury· 2 shared A. C. N. Vasconcelosi· 1 shared A. P. Feinberg· 1 shared A. Sen· 1 shared B. Farrell· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

Y. Li

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

Q. Ni, Z. Ge, Y. Li, G. Shatkin, J. Fu, K. Bera, Y. Yang, Y. Wang, A. Sen, Y. Wu, A. C. N. Vasconcelosi, A. P. Feinberg, K. Konstantopoulos, S. X. Sun

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

bioRxiv · Aug 31, 2023Biophysics

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

M. M. Mallin, N. Kim, M. I. Choudhury, S. J. Lee, S. S. An, S. X. Sun, K. Konstantopoulos, K. J. Pienta, S. R. Amend

The paper identifies Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells through increased motility, elasticity, and survival in circulation.

bioRxiv · Sep 16, 2022Cancer Biology

The Correlation Between Cell and Nucleus Size is Explained by an Eukaryotic Cell Growth Model

Y. Wu, P. Janmey, S. X. Sun

The paper develops a computational model of cell growth and proteome increase to explain the correlation between cell and nuclear volume, showing that transport rates and ribosome dynamics influence growth and volume ratios.

bioRxiv · Sep 1, 2021Cell Biology

Trans-epithelial Fluid Pumping Performance of Renal Epithelial Cells and Mechanics of Cystic Expansion

M. I. Choudhury, Y. Li, P. Mistriotis, E. E. Dixon, J. Yang, D. Maity, R. Walker, M. Benson, L. Martin, F. Koroma, F. Qian, K. Konstantopoulos, O. M. Woodward, S. X. Sun

This study uses a microfluidic platform to show renal epithelial cells generate hydraulic pressure gradients, with PKD cells showing reversed fluid flow and higher stall pressure.

bioRxiv · Aug 6, 2019Biophysics

Transition from actin-driven to water-driven cell migration depends on external hydraulic resistance

Y. Li, S. X. Sun

The paper develops a theoretical model showing how cell migration transitions from actin-driven to water-driven mechanisms based on environmental constraints.

bioRxiv · Mar 8, 2018Cell Biology

Electromechanics and Volume Dynamics in Non-excitable Tissue Cells

F. Yellin, Y. Li, V. K. A. Sreenivasan, B. Farrell, M. B. Johny, D. Yue, S. X. Sun

This study investigates how cell volume in non-excitable tissue cells is regulated by membrane potential and ion concentrations, showing volume changes under different conditions.

bioRxiv · Mar 8, 2018 · PreprintBiophysics

Role of Membrane-tension Gated Ca Flux in Cell Mechanosensation

L. He, J. Tao, F. Si, Y. Wu, T. Wu, V. Prasath, D. Wirtz, S. X. Sun

The paper demonstrates that membrane tension-sensitive calcium currents and ion channels regulate Rho GTPase and myosin contraction, and that YAP translocates in response to mechanical compression.

bioRxiv · May 4, 2017Cell Biology