S.-J. Gao

Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

This study shows that dexamethasone inhibits KSHV-induced inflammation and tumorigenesis by activating GR signaling, which suppresses IL-1 and induces IL-1Ra.

METTL16 Controls Kaposi's Sarcoma-Associated Herpesvirus Replication by Regulating S-Adenosylmethionine Cycle

This study shows METTL16 suppresses KSHV lytic replication by regulating the SAM cycle and redox homeostasis.

N6-methyladenosine (m6A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

Pseudomonas aeruginosa Stimulates Inflammation and Enhances KSHV-Induced Cell Proliferation and Cellular Transformation through Both LPS and Flagellin

This study shows that Pseudomonas aeruginosa enhances inflammation and cell proliferation in KSHV-transformed cells via LPS and flagellin, highlighting potential therapeutic targets for AIDS-KS patients.

CRISPR-Cas9 screening of KSHV-transformed cells identifies XPO1 as a vulnerable target of cancer cells

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

Repurposing cytarabine for treating primary effusion lymphoma by targeting KSHV latent and lytic replications

This study identifies cytarabine as a potent inhibitor of KSHV-induced primary effusion lymphoma by targeting both viral and host DNA/RNA synthesis and inducing tumor regression in a xenograft model.