Author

G. D. Katkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2

Frequent Co-Authors

P. Ghosh· 6 shared V. Castillo· 4 shared C. R. Espinoza· 3 shared D. Sahoo· 3 shared S. Das· 3 shared S. Sinha· 3 shared M. S. Anandachar· 2 shared S.-R. Ibeawuchi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersImmunology

P. Ghosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism

M. S. Anandachar, S. Roy, S. Sinha, B. Agyekum, S.-R. Ibeawuchi, H. Gementera, A. Amamoto, G. D. Katkar, P. Ghosh

The paper identifies a conserved molecular interface between WxxxE-effector proteins from gut pathogens and the host protein ELMO1, showing how pathogens exploit the host's engulfment pathway.

bioRxiv · Apr 9, 2023Immunology

Coupling of NOD2 to GIV is Required for Bacterial Sensing

G. D. Katkar, M. S. Anandachar, S. Sinha, S.-R. Ibeawuchi, C. R. Espinoza, J. Coates, Y. S. Malhotra, M. Mullick, V. Castillo, D. T. Vo, D. Sahoo, P. Ghosh

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

bioRxiv · Apr 26, 2022 · PreprintImmunology

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

S. Sinha, V. Castillo, C. R. Espinoza, C. Tindle, A. G. Fonseca, J. M. Dan, G. D. Katkar, S. Das, D. Sahoo, P. Ghosh

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

bioRxiv · Nov 28, 2021Immunology

GIV/Girdin, a Non-receptor Modulator for Gαi/s, Regulates Spatiotemporal Signaling during Sperm Capacitation and is Required for Male Fertility

S. Reynoso, V. Castillo, G. D. Katkar, I. Lopez-Sanchez, S. Taheri, C. R. Espinoza, C. Rohena, D. Sahoo, P. Gagneux, P. Ghosh

This study shows GIV/Girdin regulates spatiotemporal signaling during sperm capacitation and is essential for male fertility by modulating distinct signaling programs in sperm tail and head.

bioRxiv · May 6, 2021Cell Biology

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

E. M. Muntjewerff, K. Tang, L. Lutter, G. Christoffersson, M. J. T. Nicolasen, H. Gao, G. D. Katkar, S. Das, M. t. Beest, W. Ying, P. Ghosh, S. El Aidy, B. Oldenburg, G. van den Bogaart, S. K. Mahata

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

bioRxiv · Sep 19, 2020Physiology

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

L. A. B. Swanson, G. D. Katkar, J. Tam, R. Pranadinata, Y. Chareddy, J. E. Coates, M. S. Amandachar, V. Castillo, J. Olson, V. Nizet, I. Kufareva, S. Das, P. Ghosh

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

bioRxiv · Aug 29, 2020Immunology