Edith A. Paxton

Restricted expression site use and extreme genome diversification drives trypanosome antigenic variation in chronic bovine infections

The paper analyzes antigenic variation in Trypanosoma brucei during chronic bovine infections, revealing enhanced diversity and a reproducible temporal expression hierarchy of VSGs.

A high-resolution atlas of cattle regulatory variants and their cross-species activity in matched human cells

The paper creates a high-resolution cattle regulatory variant atlas and identifies cross-species activity in human cells, highlighting both conservation and species-specific effects.

Comparative lipidomic profiling of the livestock pathogens Trypanosoma congolense and Trypanosoma brucei

This study compares lipidomic profiles of Trypanosoma congolense and Trypanosoma brucei to understand their metabolic differences and implications for in vitro culture and therapy development.

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomiasis

This paper develops a Cas10-based lateral flow assay for detecting 7SL-sRNA in cattle with active trypanosomiasis, showing high sensitivity and specificity during chronic infection phases.

Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia

This study identifies cryptic stumpy-like T. brucei forms in cattle with low parasitaemia, challenging rodent-based assumptions about stumpy form differentiation.

Title Longitudinal Observational (single cohort) Study on the Causes of Trypanocide Failure in cases of African Animal Trypanosomosis in Cattle Near Wildlife Protected Areas of Northern Tanzania

This study identifies factors contributing to trypanocide failure in cattle with African animal trypanosomosis in Tanzania, finding drug quality, improper use, and resistance as key issues.

Continent-wide genomic analysis of the African buffalo (Syncerus caffer).

This study presents a continent-wide genomic analysis of African buffalo, revealing three main lineages and signatures of selection related to immune response.

A locus conferring tolerance to Theileria infection in African cattle

The paper identifies a genetic locus associated with tolerance to Theileria parva infection in cattle, showing a strong heritability and replication across cohorts.

A cattle graph genome incorporating global breed diversity

The paper creates a graph genome incorporating global cattle diversity, showing it includes more sequence and improves mapping and variant calling.

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

This study uses long-read sequencing to analyze VSG diversity in T. brucei infections, revealing higher expressed diversity and early mosaic gene formation than previously observed.