Author

Sachin Khurana

The University of Melbourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christopher J. TonkiniD· 3 shared Alessandro D. Uboldi· 2 shared Nichollas E. ScottiD· 2 shared Alan John· 1 shared Alexandra L. GarnhamiD· 1 shared Alyssa E. BarryiD· 1 shared Amalie A Jaywickrama· 1 shared Amber Simonpietri· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

Christopher J. TonkinORCID

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3 papers

Recent·Most cited

Differentiation of Toxoplasma into latent forms is linked to central carbon metabolism and requires a GID/CTLH-type E3 ubiquitin ligase

Alessandro D. Uboldi, Sachin Khurana, Amalie A Jaywickrama, Sai Prasanna Lekkala-Lethakula, Amber Simonpietri, Karan Singh, Vinzenz Hofferek, Ushma Ruparel, Lachlan L Whitehead, Kelly L. Rogers, Alexandra L. Garnham, Nichollas E. Scott, Nicholas J. Katris, Malcolm J. McConville, David Komander, , Christopher J. Tonkin

This study identifies glucose-limiting conditions and a GID/CTLH-type E3 ubiquitin ligase as key factors in Toxoplasma differentiation into latent forms.

bioRxiv · Jul 27, 2025 · PreprintMicrobiology

The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite Plasmodium falciparum through interference with actin-1/profilin dynamics

Madeline G. Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Sujaan Das, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Maria R. Gancheva, Christopher J. Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey Ian McFadden, , Paul R. Gilson

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.

bioRxiv · Sep 29, 2022 · PreprintMolecular Biology

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

Sachin Khurana, Michael J. Coffey, Alan John, Alessandro D. Uboldi, My-Hang Huynh, Rebecca J. Stewart, Vern B. Carruthers, Christopher J. Tonkin, Ethan D. Goddard-Borger, Nichollas E. Scott

This study shows that O-glycosylation of MIC2 by TgPOFUT2 is not essential for Toxoplasma gondii tachyzoite infectivity and plaque formation.

bioRxiv · Aug 14, 2018 · PreprintMicrobiology