Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Feizhi Song, Valerija Kovač, Behnam Mohammadi, Jessica Lisa Littau, Franka Scharfenberg, Andreu Matamoros‐Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Salma Djakkani, Luise Linsenmeier, Maja Černilec, Katrina Pretnar Hartman, Sebastian Jung, , Hermann C. Altmeppen
This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.
Acta Neuropathologica · Jul 9, 2024Peer-reviewedNeuroscience