Author

Samantha L. Killiany

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:proteomics· 1

Frequent Co-Authors

Amita SehgaliD· 4 shared Zhifeng Yue· 3 shared Caitlin E. RandolphiD· 2 shared Camilo GuevaraiD· 2 shared Connor H. Beveridge· 2 shared Elana S. PyfromiD· 2 shared Gaurav ChopraiD· 2 shared Yongjun LiiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Amita SehgalORCID

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Author profile →

4 papers

Recent·Most cited

Sleep-dependent clearance of brain lipids by peripheral blood cells

Bumsik Cho, Diane E. Youngstrom, Samantha L. Killiany, Camilo Guevara, Caitlin E. Randolph, Connor H. Beveridge, Pooja Saklani, Gaurav Chopra, Amita Sehgal

The paper shows that sleep in Drosophila allows peripheral hemocytes to clear lipids from the brain, and this process is mediated by the eater receptor.

Nature · Feb 11, 2026Peer-reviewedMolecular Biology

Sleep controls peroxisomal abundance to reduce wake-induced brain oxidation

Camilo Guevara, Yongjun Li, Elana S. Pyfrom, Samantha L. Killiany, Zhifeng Yue, Amita Sehgal

This study shows that sleep regulates peroxisomal abundance to reduce brain oxidation caused by wakefulness, with Pex16 playing a key role in sleep regulation and lipid metabolism.

bioRxiv · Nov 28, 2025 · PreprintNeuroscience

Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

Elana S. Pyfrom, Connor H. Beveridge, Paula R. Haynes, Vishal A. Kanigicherla, Caitlin E. Randolph, Paula Carvalho Costa, Seble G. Negatu, Sanjay N. Iyer, Samantha L. Killiany, Zhifeng Yue, Erick Astacio, Katherine A. Walker, Kiet N. Luu, Pavel Pivarshev, Kellie A. Jurado, , Amita Sehgal

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

bioRxiv · Sep 10, 2025 · PreprintNeuroscience

Sleepiness, not total sleep amount, increases seizure risk

Vishnu Anand Cuddapah, Cynthia T. Hsu, Yongjun Li, Hrishit M Shah, Christopher Saul, Samantha L. Killiany, Joy H. Shon, Zhifeng Yue, Gabrielle L. Gionet, Mary E. Putt, Amita Sehgal

The paper shows that sleepiness, not total sleep amount, increases seizure risk in Drosophila models by identifying the role of sleep-promoting circuits and serotonin receptors.

bioRxiv · Sep 30, 2023 · PreprintNeuroscience