Dual MYC and GSPT1 Protein Degrader for MYC-Driven Cancers
Yuki Nishida, Valeria Impedovo, Edward Ayoub, Natalia Baran, Darah A Scruggs, Hideaki Mizuno, Shayaun Khazaei, Lauren B. Ostermann, Sandeep Singh, Andrea D. Bedoy, Po Yee Mak, Bing Z. Carter, Eiji Sugihara, Tetsuya Takimoto, Youzhi Tong, , Michael Andreeff
This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.
bioRxiv · Apr 24, 2025 · PreprintCancer Biology