Author

Sathish Kumar Ramakrishnan

Yale UniversityORCID 0000-0002-7844-2234Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

James Edward RothmaniD· 3 shared Jeff ColemaniD· 3 shared Manindra BeraiD· 3 shared Abhijith RadhakrishnaniD· 2 shared Ramalingam Venkat Kalyana SundaramiD· 2 shared Shyam Sundar KrishnakumariD· 2 shared Aditi NaskariD· 1 shared Advaith Nair· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

James Edward RothmanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Curvature-Encoded Photochemistry for Programmable Isolation and Fractionation of Extracellular and Plasma Membrane Vesicles

Jennifer Pichurin, Advaith Nair, Amelia Williams, Sikha Thoduvayil, Abhijith Radhakrishnan, Sudhanshu Gautam, Aditi Naskar, Pallavi P. Gopal, Themis R. Kyriakides, Sathish Kumar Ramakrishnan, Roshan W. Gunasekara

This paper develops a light-activated platform for isolating and fractionating lipid-based nanovesicles with high purity and scalability.

bioRxiv · Dec 30, 2025 · PreprintBioengineering

Synaptophysin Chaperones the Assembly of 12 SNAREpins under each Ready-Release Vesicle

Manindra Bera, Abhijith Radhakrishnan, Jeff Coleman, Ramalingam Venkat Kalyana Sundaram, Sathish Kumar Ramakrishnan, Frédéric Pincet, James Edward Rothman

This paper identifies Synaptophysin as a chaperone that organizes 12 SNAREpins under each synaptic vesicle through its hexamer structure and VAMP2 dimer binding.

Proceedings of the National Academy of Sciences · Oct 30, 2023Peer-reviewedNeuroscience

Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery

Ramalingam Venkat Kalyana Sundaram, Atrouli Chatterjee, Manindra Bera, Kirill S. Grushin, Aniruddha Panda, Feng Li, Jeff Coleman, Seong Lee, Sathish Kumar Ramakrishnan, Andreas Max Ernst, Kallol Gupta, James Edward Rothman, Shyam Sundar Krishnakumar

The paper reconstitutes core synaptic machinery to reveal DAG's role in vesicle priming and Ca2+-triggered release, showing DAG accelerates SNAREpin assembly and affects release dynamics.

bioRxiv · Jun 5, 2023 · PreprintNeuroscience

Independent Yet Synergistic Roles of Synaptotagmin-1 and Complexin in Calcium Regulated Neuronal Exocytosis

Sathish Kumar Ramakrishnan, Manindra Bera, Jeff Coleman, James E. Rothman, Shyam Sundar Krishnakumar

This study investigates the independent yet synergistic roles of Synaptotagmin-1 and Complexin in calcium-regulated neuronal exocytosis using a reconstituted single-vesicle fusion assay.

bioRxiv · Dec 16, 2019 · PreprintNeuroscience