Frédéric Pincet

Controlling membrane tension by dynamic DNA nanorings

This paper introduces DNA nanorings to dynamically control membrane tension in sub-100 nm liposomes, enabling controlled mechanical stress and molecular cargo release.

Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release

This study shows that two Munc13 oligomers are essential for vesicle docking and SNARE assembly, supporting neurotransmitter release.

Synaptophysin Chaperones the Assembly of 12 SNAREpins under each Ready-Release Vesicle

This paper identifies Synaptophysin as a chaperone that organizes 12 SNAREpins under each synaptic vesicle through its hexamer structure and VAMP2 dimer binding.

Actuating tension-loaded DNA clamps drives membrane tubulation

This paper demonstrates DNA clamps that, when triggered by specific signals, induce membrane tubulation in GUVs by releasing stored energy through conformational changes.

Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly

The paper shows Munc13-1 directly binds SNAP25 to initiate SNARE complex assembly, using FRET and optical tweezer techniques.