An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting
Alex F. F. Crozier, Kunal M. Shah, Paul Grevitt, Anisha Thind, Eleni Maniati, Jun Wang, Kylie A. Shen, Diana Cox, Vinothini Rajeeve, Pedro R. Cutillas, Dimitris Lagos, Faraz K. Mardakheh, Sam Griffiths‐Jones, Antonio De Marco, Tyson V. Sharp
This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.
bioRxiv · Oct 7, 2025 · PreprintMolecular Biology