Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition
Xuefei Chen, H. Diessel Duan, Michael J. Hoy, Kalinka K. Koteva, Michaela Spitzer, Allison K. Guitor, Emily Puumala, Aline Fiebig‐Comyn, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Amelia Bing Ya Guo, Wenliang Wang, , Gerard D. Wright
The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.
Cell · Dec 31, 2025Peer-reviewedBiochemistry