Author

Kalinka K. Koteva

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0000-0002-6446-9567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Gerard D. WrightiD· 5 shared Allison K. GuitoriD· 2 shared David SychanthaiD· 2 shared Eric D. BrowniD· 2 shared Michael A. CookiD· 2 shared Wenliang Wang· 2 shared A. Wei· 1 shared Aline Fiebig‐ComyniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersMicrobiology

Gerard D. WrightORCID

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Author profile →

5 papers

Recent·Most cited

Exploring the antibiotic-producing capabilities of Canadian High Arctic bacteria

Eszter Farkas, Maja Lambeck, Grace Parish, Laurence Belanger, Daniella Serrador, Mina Nekouei, Kalinka K. Koteva, François Le Mauff, Patrick Lypaczewski, B. Jesse Shapiro, Lyle Whyte, Gerard D. Wright, Karine Auclair, Samantha Gruenheid, Dao Nguyen

This study screens Arctic bacteria to discover antibacterial compounds, identifying koreenceine A from a Pseudomonas isolate and confirming its antibiotic activity through genetic analysis.

bioRxiv · Oct 12, 2026 · PreprintMicrobiology

Vacidobactin A: An anti-Pseudomonas aeruginosa siderophore

Manpreet Kaur, Derek C. K. Chan, Hodan Wardere, Wenliang Wang, Allison K. Guitor, Kalinka K. Koteva, Lori L. Burrows, Gerard D. Wright

This paper identifies vacidobactin A, a siderophore from Variovorax paradoxus, that inhibits Pseudomonas aeruginosa growth by limiting iron availability and synergizes with thiostrepton.

bioRxiv · Mar 2, 2026 · PreprintMicrobiology

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

Xuefei Chen, H. Diessel Duan, Michael J. Hoy, Kalinka K. Koteva, Michaela Spitzer, Allison K. Guitor, Emily Puumala, Aline Fiebig‐Comyn, Guanggan Hu, Bonnie Yiu, Sommer Chou, Zhuyun Bian, Yeseul Choi, Amelia Bing Ya Guo, Wenliang Wang, , Gerard D. Wright

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

Cell · Dec 31, 2025Peer-reviewedBiochemistry

A ubiquitous Streptomyces biosynthetic megacluster encodes an arsenal of synergistic biotin-targeting antibiotics

Rodion Gordzevich, Min Xu, W. Wang, Michael A. Cook, Dirk Hackenberger, Julia Patricia Deisinger, Megan M. Tu, Lindsey A. Carfrae, M. George, Kenneth Rachwalski, Kalinka K. Koteva, David Sychantha, A. Wei, Gerard D. Wright, Eric D. Brown

The paper identifies a conserved Streptomyces biosynthetic megacluster producing biotin-targeting antibiotics, effective against multidrug-resistant E. coli.

bioRxiv · Oct 9, 2025 · PreprintMicrobiology

The histidine kinase VraS orchestrates the cell-wall stress response in Staphylococcus aureus via its direct interaction with glycopeptides and β-lactams

Melisa B. Antinori, David Sychantha, Kalinka K. Koteva, Irina P. Suárez, Melani D. Peralta, Gerard D. Wright, Leticia Irene Llarrull

This study identifies VraS as a direct receptor for vancomycin and ampicillin, revealing its role in activating the cell-wall stress response in Staphylococcus aureus and providing a target for combating antibiotic resistance.

bioRxiv · Jan 23, 2025 · PreprintBiochemistry