Author

Shreya Rajachandran

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Haiqi CheniD· 4 shared Xin ZhangiD· 4 shared Karla J. Saner· 2 shared Kyle E. OrwigiD· 2 shared Melanie Evans· 2 shared Orhan BükülmeziD· 2 shared Qianlan XuiD· 2 shared Qiqi CaoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersGenomics

Haiqi ChenORCID

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Author profile →

4 papers

Recent·Most cited

Extrachromosomal Circular DNA Function as Mobile Elements to Alter the Mammalian Germline Genome

Xin Zhang, Melanie Evans, Shreya Rajachandran, Angie Huang, Yanfeng Zhang, Karla J. Saner, Lin Xu, Kyle E. Orwig, Remus Stana, Orhan Bükülmez, Vladimir B. Seplyarskiy, Haiqi Chen

This study shows that extrachromosomal circular DNA (eccDNA) in the male germline can integrate into the genome and contribute to structural variations, with diabetes increasing eccDNA levels in sperm.

bioRxiv · Sep 7, 2026 · PreprintDevelopmental Biology

ECHOS enables spatial epigenome profiling at subcellular resolution

Qiqi Cao, Qianlan Xu, Yusuke Ueda, Shreya Rajachandran, Manjita Sharma, Xin Zhang, Mala Mahendroo, Edward J. Grow, Haiqi Chen

ECHOS enables spatial epigenome profiling at subcellular resolution by combining high-resolution imaging and high-throughput sequencing, revealing distinct gene regulatory logics and epigenetic changes in human tissues.

bioRxiv · Mar 27, 2026 · PreprintGenetics

Subcellular Level Spatial Transcriptomics with PHOTON

Shreya Rajachandran, Qianlan Xu, Qiqi Cao, Xin Zhang, Fei Chen, Sarah M. Mangiameli, Haiqi Chen

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

Nature Communications · May 14, 2025Peer-reviewedGenomics

Functional and Clinical Implications of Extrachromosomal Circular DNA in the Human Germline

Melanie Evans, Shreya Rajachandran, Xin Zhang, Yanfeng Zhang, Karla J. Saner, Lin Xu, Kyle E. Orwig, Orhan Bükülmez, Haiqi Chen

This study identifies eccDNA in human male germline and links its abundance to chronic diseases through transcriptional activity and apoptosis signaling.

bioRxiv · Jun 2, 2024 · PreprintGenomics