Xin Zhang

This study shows that extrachromosomal circular DNA (eccDNA) in the male germline can integrate into the genome and contribute to structural variations, with diabetes increasing eccDNA levels in sperm.

ECHOS enables spatial epigenome profiling at subcellular resolution by combining high-resolution imaging and high-throughput sequencing, revealing distinct gene regulatory logics and epigenetic changes in human tissues.

This study establishes an HEV-HIE model showing HEV replication in intestinal epithelial cells, with proliferative cells being the main targets, suggesting the gut as an HEV reservoir.

The paper uses spatial proteomics to show IDO1's tumor-suppressive role in ovarian cancer by linking it to tryptophan metabolism and stress response pathways.

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

This study identifies eccDNA in human male germline and links its abundance to chronic diseases through transcriptional activity and apoptosis signaling.

This study shows that transcription factor condensates cluster target genes and enhance their expression in response to methionine starvation in yeast.

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

This study identifies cAMP as an endogenous inhibitor of PD-1/PD-L1 binding through a combination of experimental and computational methods.

This study identifies PABPN1L as essential for maternal mRNA degradation during maternal-to-zygotic transition, with variants linked to female infertility.