Author

Sierra Harken

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

Aaron LeongiD· 1 shared Adam Štefek· 1 shared Addie Petersen· 1 shared Alexander Crits‐ChristophiD· 1 shared Alham Saadat· 1 shared Alina AinbinderiD· 1 shared Allison Lord· 1 shared Alycen M. HarneyiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperGenomics

Aaron LeongORCID

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Author profile →

3 papers

Recent·Most cited

Active learning guides automated discovery of DNA delivery via electroporation for non-model microbes

Stephanie L. Brumwell, Allison Lord, Anna D. Corts, Sierra Harken, Alexander Crits‐Christoph, Mary-Anne Nguyen, Julia Leung, Kerrin Mendler, Ariela Esmurria, Charlie Gilbert, Lilan Ling, Henry H. Lee, Nili Ostrov

This paper develops an automated platform using active learning to discover electroporation protocols for non-model microbes, achieving higher transformation efficiency for industrial chassis.

bioRxiv · Nov 18, 2025 · PreprintMicrobiology

Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler

Samantha Laber, Sophie Strobel, Josep Maria Mercader, Hesam Dashti, Felipe R. C. dos Santos, Phil Kubitz, Maya Jackson, Alina Ainbinder, Julius Honecker, Saaket Agrawal, Garrett Garborcauskas, David R. Stirling, Aaron Leong, Katherine Figueroa, Nasa Sinnott-Armstrong, , Melina Claussnitzer

The paper introduces LipocyteProfiler, a high-throughput microscopy assay to profile lipid-storing cells and identifies cellular programs linked to metabolic traits like insulin resistance and lipodystrophy.

Cell Genomics · Jun 20, 2023Peer-reviewedGenomics

Getting there and staying there: supporting and enabling persistent human life on Mars using synthetic natural rubber, self-healing materials, and biological batteries.

Nischal Acharya, Natalie Baker, Marilu Krystal Bravo, Katie Gu, Sierra Harken, Michael Howland Herschl, Addie Petersen, Ileana Pirozzi, Dylan Spangle, Gordon L. Sun, Brian B. Vuong, Nils J. H. Averesch, Kosuke Fujishima, Trevor J. Kalkus, Kara J. Helmke Rogers, Lynn J. Rothschild

The paper proposes using biological solutions like self-healing materials, biobatteries, and synthetic rubber-producing bacteria to enhance sustainability and reduce costs for Mars exploration.

bioRxiv · Jun 12, 2018 · PreprintSynthetic Biology