Cross-Cohort Optimal Transport Maps Macrophage Plasticity and Competing Routes to Inflammation and Fibrosis in Human Atherosclerotic Plaques
Sergio Vazquez Montes de Oca, Ariadna Acedo-Terrades, Jose F Carreno Martinez, Philipp Kirchner, Tiit Örd, Minna Unelma Kaikkonen, Siting Wei, Stefan Freigang, Inti Zlobec, María Rodríguez Martínez
The paper develops a computational framework using optimal transport to analyze macrophage state transitions in atherosclerosis, identifying origin-dependent plasticity mechanisms and shared regulatory circuits in inflammation and fibrosis.
bioRxiv · Aug 20, 2026 · PreprintBioinformatics