Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability
Jennifer A. Brain, Sarah M Chang, Maximilian Kobiesa, Leah G. Rector, Michele Ceribelli, Sky H. Kim, Zhaoqi Li, Brian T. Do, Kelli J. Che, David O. Holland, Samuel Block, Renee Chang, Gillian E. Oaks, Craig J. Thomas, Matthew G. Vander Heiden, Lucas B. Sullivan
This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.
bioRxiv · Jul 7, 2026 · PreprintCancer Biology